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Part 6. Are M&S outputs real?
TL; DR Once the model is suitably validated, it will predict the therapy’s efficacy. This prediction is based on knowledge that science assumes real, and applied to virtual data,…
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Part 5. Examples of Effect Model applications
TL; DR The EM serves to run in silico clinical trials cheaper and faster than in vivo clinical trials. EM can be applied from discovery (target selection) to market access (translating trial…
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Part 4. Responders - the M&S perspective
TL; DR One of the most promising contributions of M&S to R&D is the identification of responders. This aspect approaches the field of personalized medicine.…
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Part 3. NOVA’s Modeling and Simulation approach
TL; DR Clinical outcome is an ultimate focus of the M&S process. Six-steps process consists of: Problem formulation (project plan), Systemic knowledge review (knowledge model), Computational model,…
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Part 2. NOVA’s approach reconciles knowledge with data to predict clinical outcomes
TL; DR The M&S approach in MIDD should be designed and operated for the patient's health (in the form of clinical outcome). The M&S is the mix of the top-down problem solving approach and the…
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Part 1. Introductory remarks
TL; DR Models are just simplified representation of a real world with some constraints, which quickly become obsolete and need to be updated from time to time.…
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NOVA’s approach to Model Informed Drug Development
Jules Henri Poincaré (French mathematician, 1854-1912) Science is facts; just as houses are made of stone, so is science made of facts; but a pile of stones is not a house,…
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Import an SBML document in jinkō
You can import SBML models in jinkō following the same instructions as in here except that the document to upload is a valid SBML file. Supported SBML versions Jinkō supports all SBML versions up to…
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Onboarding tutorial: practical use cases
This tutorial is accompanied by a content package on Jinko.ai which contains: A computational model, implemented from the work of Ma et al. (2021), named Ma et al - Preclinical QSP model TCE inside…
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L to P
L Ligand Substance that binds specifically and reversibly to a biomolecule to form a complex (e.g. an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor,…
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D to K
D Data Set of values of a qualitative or quantitative variables observed on a defined set of subject (e.g. patients). It refers to the information obtained from a single statistical units in an…
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A to C
A Absolute benefit Difference between the untreated/control risk or rate (respectively individual/group-average prediction, or event on an observed group) and the corresponding treated risk or rate…
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How many groups and projects can I create in jinkō?
There is no limit to the number of groups and projects you can create on the jinkō platform. They are here to help you organize your work. For each group,…
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Visualize results in jinkō
Context & main goals This tutorial assumes that you have already created and launched a trial in jinkō. Should you not have completed this step, you can refer to the following link:…
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How to create a measure
Note: this tutorial assumes that you have already uploaded in jinkō a Computational Mode. Should you not have completed this step, you can refer to the following link:…
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Setting up protocol arms for your trial
Note: this tutorial assumes that you have already uploaded or created in jinkō a Computational Mode. Should you not have completed this step, you can refer to one of the following links:…
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Set up and use your workspace in jinkō
The jinkō platform offers a structured and collaborative approach to in-silico modeling. The steps below provide an overview of the platform structure, so you can quickly get started with your first…
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How to use the 'Linked by' and 'Linked to' features?
In any item in jinkō, you can click on ‘Linked to vs Linked by’ on the right-side app panel, to navigate to items that are linked: 'Linked to' displays all the project items to which a particular…
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Adding equations from a model in a document
Once you have integrated your Computational Model (CM) into the jinkō platform, you can add equations issued from it directly in a Document, in a way to tie scientific discursive knowledge / facts…
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Litterature review and knowledge curation in jinkō
The jinkō platform offers a powerful set of features allowing for the human-curation of scientific knowledge behind a computational model and/or a research project.…
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Creating a trial in jinkō
Note: this tutorial assumes that you have already uploaded in jinkō a Computational Model. Should you not have completed this step, you can refer to the following links:…
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Use of comments in a document
See existing comments Before adding your own comments, it can be useful to see if there are existing ones. To do so, upon opening the document, click on the Discussion bubble in the right-hand side…
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What is jinkō? Core concepts and typical project workflows
Learn more here on what jinkō is and what are typical steps of an in-silico trial project using the platform. Jinkō's core concepts 'White-box' simulations:…
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When I comment in the Communication Feed, are my mentioned colleagues automatically notified ?
Yes, to do so, simply start typing in your comment an '@', this will trigger the list of available members from your team who can can tag. As a result, your teammate will receive an email…
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When I create a document, I have an option to link it with other items. What is the difference between 'Linked to' and 'Linked by'?
Indeed, when you create the document, you get the whole spectrum of functionalities that makes it simple to add references to items created in your project. One of them is linking.…